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"Research Points to Potential Shortcoming of Antibiotic Lab Tests"

7/12/2018

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Our inoculum effect manuscript in the journal Antimicrobial Agents and Chemotherapy highlighted in BIDMC news release.
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Congratulations to KP Smith on Inoculum Effect manuscript acceptance in AAC

5/26/2018

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"The Inoculum Effect in the Era of Multidrug Resistance: Minor Differences in Inoculum Have Dramatic Effect on Minimal Inhibitory Concentration Determination."

The manuscript describes use of D300-based inkjet printing technology to investigate the inoculum effect with a resolution not previously possible.  The inoculum effect is the general observation that the minimal inhibitor concentration (in other words level of resistance) of an organism to an antibiotic increases when a higher density of organisms is tested.   This is effect is especially prominent for beta-lactam antiibiotics.  It is of potential clinical concern during some types of infections when the organism burden is high.  Here we explored whether subtle differences in inoculum within the range allowed by current standards can effect the susceptibility testing results that clinical laboratories obtain and provide to clinicians.  Our findings for organisms with certain types of multidrug-resistance and very important classes of antibiotics was that these small allowable differences in inoculum could change the MIC determinations and the determination of whether organisms were susceptible or resistant to the antibiotics tested.

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Congratulations to KP Smith who has won an "Outstanding Abstract Award"

3/28/2018

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KP Smith wins an "Outstanding Abstract Award" otherwise known as the OAA, for his experimental work on the inoculum effect. 

The award description on the ASM Microbe 2018 awards website:  "Sponsored by ASM and determined by the ASM Microbe Program Committee, these awards highlight outstanding abstracts presented by students, residents, or medical/clinical fellows. All abstracts submitted by the deadline will be considered for these awards. Awards will include a cash prize of $200."  
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Fun with Inkjet Printer

3/15/2018

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Picture
Lab art with HP D300 digital dispensing system. Crystal violet blue, phenol red, background droplets.
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KP Smith Poster Talk at ASM Microbe

9/30/2017

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Picture
KP Smith Presents MAST Inkjet Technology at 2017 ASM Microbe Meeting
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Our work cited in FDA Public Workshop on Antimicrobial Susceptibility and Resistance: Addressing Challenges of Diagnostic Devices, September 13, 2017

9/30/2017

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In her presentation on "Efforts and Resources for Addressing Antimicrobial Resistance,"  Dr. Jean Patel,, Science Lead, ARX Unit,, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, describes potential use of digital dispensing inkjet technology for establishing on-demand MIC testing at ALRN labs.  Dr. Patel's slide presentation is available from the FDA website.  
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MAST:  Microscopy-Based Antimicrobial Susceptibility Testing now at local grocery store

8/20/2017

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Picture
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Congratulations to postdoctoral fellow KP Smith and colleagues for acceptance of SLAS Technology Manuscript

8/5/2017

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Smith KP, Richmond DL, Brennan-Krohn T, Elliott HL, Kirby JE. Development of MAST: a Microscopy-Based Antimicrobial Susceptibility Testing Platform.  SLAS Technology,  ​In press.    

Use of inkjet printing, advanced imaging, and machine learning to achieve reference standard, microdilution antimicrobial susceptibility testing readout in two hours with off-the-shelf supplies.   For any antimicrobial at will.

Update:  Now Published On-Line in SLAS Technology Website!
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3 Posters Presented by Lab Members at ASM Microbe 2017 Meeting

7/7/2017

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Congratulation to Thea Brennan-Krohn!

7/7/2017

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.On acceptance of her manuscript by the Journal of Antimicrobial Chemotherapy:  

Brennan-Krohn T, Truelson KA, Smith KP, Kirby JE. Screening for synergistic activity of antimicrobial combinations against carbapenem-resistant Enterobacteriaceae using inkjet printer-based technology. J Antimicrobial Chemotherapy. 2017 July.

Link to abstract.  Link to Journal Full Text. 
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  • Home
  • Antimicrobials
    • Legionella pneumophila
    • T4SS-dependent Gram negative pathogens
    • CRE Pathogens
    • Mechanisms of carbapenem resistance >
      • Carbapenemases | KPC | NDM-1
      • Porins
      • Efflux pumps
  • Diagnostics
  • SARS-CoV-2
  • Pathogenesis
  • About the PI
  • Personnel
  • Publications
  • Blog
  • Environment
  • Positions
  • Resources
  • Major Equipment
  • Donations
  • Comments
  • Contact Info
  • Internal Lab Resources