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Our New Year's Eve manuscript acceptance, full text posting on ACS Infectious Diseases. Congratulations to members of the Manetsch and Kirby Laboratories on on line publication of: "Development of CGS-15943 Adjunctives for the Disruption of Plasmid Maintenance in Multidrug Resistant E. coli."
The manuscript describes structure activity relationship studies on a small molecule scaffold CGS-15943. The parent compound causes complete eviction of an IncFIA plasmid with highly selectivity in low, single-digit micromolar concentrations. Kate Zulauf at al. previously described identification and characterization of several potent plasmid eviction compounds in our PNAS publication. In our ACS Infectious Diseases manuscript, one portion of MInte's PhD thesis, CGS-15943 analogs were identified which were more potent than the parent compound, and with increased penetrance, An exciting step forward in our plasmid eviction work.
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