Our PloS Bio article is out! Streptothricin-F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome
Some Press Releases:
Researchers Show an Antibiotic Discovered 80 Years Ago Is Effective Against Multi-Drug Resistant Bacteria
Neglected 80-year-old antibiotic is effective against multi-drug resistant bacteria
Vergeten antibioticum kan uitkomst zijn in strijd tegen multiresistente bacteriën
Streptothricin-F (yellow spheres) bound to 16S rRNA (green) of the bacterial ribosome impinges on the decoding site where the anti-codon stem loop of the A-site tRNA (purple) binds to the codon of the mRNA (blue). This bumping of streptothricin-F into the decoding site is associated with translational infidelity (insertion of amino acids into the growing peptide chain other than those encoded for by the mRNA), ultimately leading to poisoning and death of the bacterial cell. The image was created using Pymol by alignment of PDB 7UVX containing streptothricin-F (this manuscript) with the E. coli 70S ribosome from PDB 7K00 containing mRNA and the A-site tRNA shown (DOI: 10.7554/eLife.60482).
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