The Kirby Laboratory
  • Home
  • Antimicrobials
    • Legionella pneumophila
    • T4SS-dependent Gram negative pathogens
    • CRE Pathogens
    • Mechanisms of carbapenem resistance >
      • Carbapenemases | KPC | NDM-1
      • Porins
      • Efflux pumps
  • Diagnostics
  • SARS-CoV-2
  • Pathogenesis
  • About the PI
  • Personnel
  • Publications
  • Blog
  • Environment
  • Positions
  • Resources
  • Major Equipment
  • Donations
  • Comments
  • Contact Info
  • Internal Lab Resources

Congratulations to KP Smith - Winner SLAS Early Career Member Contest

9/9/2019

0 Comments

 
Award is to attend the MassBio Digital Health Impact 2019 Symposium with SLAS Scientific Director Mike Tarselli!  Congratulations KP.   
0 Comments

New combinations and repurposed antibiotics active against the pandrug-resistant Nevada CRE, NDM-1 strain early release today in AAC

7/15/2019

1 Comment

 
Our latest manuscript: "Synergistic combinations and repurposed antibiotics active against the pandrug-resistant Klebsiella pneumoniae Nevada strain."  Antimicrobial Agents and Chemotherapy early release identifies:

Highly synergistic activity of several antimicrobial combinations.
Low apramycin and spectinomycin MIC values.

CDC previously reported that none of 26 antimicrobials they tested were active against the Nevada strain.  That made the strain until now pandrug-resistant.
 
Links to several news articles about this pandrug-resistant strain::
The Atlantic. NPR, NBC, PBS. Forbes
1 Comment

Candida auris antimicrobial discovery efforts highlighted in ContagionLive

7/5/2019

0 Comments

 
"3 Drug Combinations Appear Effective Against C auris" by Jared Kaltwasser discussed work presented by Thea Brennan-Krohn at ASM Microbe 2019.
0 Comments

Thea presenting at ACLPS Meeting

6/4/2019

0 Comments

 
Picture
There is a very fancy drawing of a single cell life form on the slide undoubtedly being compromised by a combination of antimicrobial therapeutics applied in Thea, Liam, and Sarah's experiments!
0 Comments

Postdoctoral Fellow Yoon-Suk Kang's Brucella chemical genetics screen early release today in Infection and Immunity

6/4/2019

0 Comments

 
Congratulations to Yoon-Suk on his latest Brucella neotomae manuscript: "A chemical genetics screen reveals influence of p38 map kinase and autophagy on phagosome development and intracellular replication of Brucella neotomae in macrophages"
0 Comments

Congratulions to postdoctoral fellow, KP Smith, for being selected for the Paul E Strandjord Young Investigator Award

4/12/2019

0 Comments

 
KP's abstract was selected for the Paul E Strandjord Young Investigator Award from the Academy of Clinical Laboratory Physicians and Scientists (ACLPS). He will be given an oral presentation at the ACLPS annual meeting this coming June. ACLPS is the organization that represents and promotes the discipline of academic clinical pathologists.  Congratulations KP!
0 Comments

ASM Blogs have moved

4/4/2019

0 Comments

 
ASM has reorganized their website.  Their blogs are now impossible to find, They are now organized under author pages.  Blogs from current and former research and/or clinical fellows:

​KP Smith's blogs can be found at:  www.asm.org/Biographies/Kenneth-(K-P-)-Smith
Rose Lee's blogs can be found at: www.asm.org/Biographies/Rose-Lee
Thea Brennan-Krohn's blogs can be found at:  www.asm.org/Biographies/Thea-Brennan-Krohn
Jennifer Tsang's blogs can be found at: www.asm.org/Biographies/Jennifer-Tsang
0 Comments

Congratulations to Kate Zulauf for Peggy Carter Travel Award to attend the ASM Microbe Meeting in San Francisco, CA!

2/27/2019

0 Comments

 
The ASM Peggy Cotter Travel Award Program provides funds for early career branch members, in this case, the ASM Northeast Branch, to attend the ASM Microbe Meeting, to be held this year in San Francisco, CA.  Kate will be presented her work on a small molecule screen to evict CRE resistance plasmids.
0 Comments

JoVE manuscript accepted on use of Inkjet Printing to perform antimicrobial susceptibility testing for single and drug combinations and follow up time-kill study methodology

11/29/2018

0 Comments

 
Postdoctoral fellow, Thea Brennan-Krohn, recently had a manuscript accepted in the Journal of Visualized Experimentation, aka JoVE.  The title of the manuscript and link to the abstract are "Antimicrobial Synergy Testing by the Inkjet Printer-Assisted Automated Checkerboard Array and the Manual Time-Kill Method."  We have been fielding a lot of questions over the past two years about implementation of inkjet printing antimicrobial susceptibility testing technology and thought it would be useful to share a video of the technique as well as classic time-kill analysis to analyze antimicrobial synergy. We are excited to learn that the CDC has decided to implement the technology in the near future in their Antimicrobial Resistance Laboratory Network (ARLN), initially to test, the combination of ceftazidime-avibactam and aztreonam for activity against multidrug-resistant Gram-negatives.
0 Comments

KP Smith Speaking tomorrow at Harvard Antimicrobial Resistance Laboratory Network as well as Broad Institute collaborator, Alejandro Pironti

10/31/2018

0 Comments

 
  • Kenneth P. Smith, PhD (Kirby Lab, BIDMC) “Bringing the reference laboratory to the bench: Use of inkjet printing technology for on-demand broth microdilution susceptibility testing”
  • Alejandro Pironti, PhD (Earl Lab, Broad Institute) “Carbapenemase-carrying plasmid found in three different bacterial genera in a single hospital over a nine-year span”
Symposium Description
0 Comments
<<Previous

    Kirby Lab Blog

    ​

    Follow @KirbyLabMicrobe

    RSS Feed

    Categories

    All
    Acinetobacter
    Antibiotics
    Antimicrobial Resistance
    Antimicrobial Susceptibility Testing
    Apramycin
    Artificial Intelligence
    ASM Blog
    Awards
    Brucella
    Candida Auris
    Carbapenem-Resistant Acinetobacter Baumannii (CRAB)
    Carbapenem Resistant Enterobacteriaceae
    Carbapenem-Resistant Enterobacteriaceae
    Clinical Microbiology
    Colistin
    Collaborations
    Images
    Inkjet Printing Diagnostics
    Inoculum Effect
    Klebsiella
    Lab Activities
    Lab Member News
    Legionella
    Manuscripts
    Medicinal Chemistry
    Meetings
    Microbiology And Society
    Microbiology General Interest
    MRSA
    News Release
    Postdoctoral Research
    Post Graduate Research
    Post-Graduate Research
    Staphylococcus Aureus
    Synergy
    Type IV Secretion System
    Undergraduate Research
    VISA

    Archives

    January 2025
    July 2024
    March 2024
    January 2024
    December 2023
    May 2023
    April 2023
    March 2023
    February 2023
    December 2022
    August 2022
    April 2022
    January 2022
    December 2021
    September 2021
    July 2021
    April 2021
    March 2021
    February 2021
    January 2021
    November 2020
    September 2020
    July 2020
    May 2020
    April 2020
    March 2020
    February 2020
    November 2019
    October 2019
    September 2019
    July 2019
    June 2019
    April 2019
    March 2019
    February 2019
    January 2019
    December 2018
    November 2018
    October 2018
    September 2018
    August 2018
    July 2018
    June 2018
    May 2018
    April 2018
    March 2018
    February 2018
    January 2018
    December 2017
    November 2017
    October 2017
    September 2017
    August 2017
    July 2017
    March 2017
    January 2017
    December 2016
    November 2016
    October 2016
    September 2016
    July 2016
    June 2016
    May 2016
    April 2016
    March 2016
    December 2014

    Antimicrobials
    Diagnostics
    Pathogenesis
    About the PI
    Personnnel
    Donate
  • Home
  • Antimicrobials
    • Legionella pneumophila
    • T4SS-dependent Gram negative pathogens
    • CRE Pathogens
    • Mechanisms of carbapenem resistance >
      • Carbapenemases | KPC | NDM-1
      • Porins
      • Efflux pumps
  • Diagnostics
  • SARS-CoV-2
  • Pathogenesis
  • About the PI
  • Personnel
  • Publications
  • Blog
  • Environment
  • Positions
  • Resources
  • Major Equipment
  • Donations
  • Comments
  • Contact Info
  • Internal Lab Resources