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Apramycin scaffold exploration using novel glycochemistry and SAR studies to enhance activity against Acinetobacter baumannii and other multidrug-resistant Gram-negative pathogens.
George O'Doherty
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Smith KP, Richmond DL, Brennan-Krohn T, Elliott HL, Kirby JE. Development of MAST: a Microscopy-Based Antimicrobial Susceptibility Testing Platform. SLAS Technology, In press.
Use of inkjet printing, advanced imaging, and machine learning to achieve reference standard, microdilution antimicrobial susceptibility testing readout in two hours with off-the-shelf supplies. For any antimicrobial at will. Update: Now Published On-Line in SLAS Technology Website! See: www.pnas.org/content/early/2017/01/10/1616248114.abstract. This is part of our ongoing collaboration with Ashlee Earl's group at the Broad Institute, Cambridge, MA
I was selected as a SLAS 2017 Innovation Award Finalist and will be speaking at the SLAS Annual Meeting with a presentation titled: "Inkjet Printing Technology for Facilitated At Will Antimicrobial Susceptibility Testing (FAST) in Under 5 Hours: Addressing the Needs of a So-Called 'Post-Antibiotic Era'.
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