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Kirby Lab Outing to Tiger Mama, Boston, MA

7/21/2019

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Candida auris antimicrobial discovery efforts highlighted in ContagionLive

7/5/2019

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"3 Drug Combinations Appear Effective Against C auris" by Jared Kaltwasser discussed work presented by Thea Brennan-Krohn at ASM Microbe 2019.
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Thea presenting at ACLPS Meeting

6/4/2019

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There is a very fancy drawing of a single cell life form on the slide undoubtedly being compromised by a combination of antimicrobial therapeutics applied in Thea, Liam, and Sarah's experiments!
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Great week for graduate school/medical school admissions (congratulations to Liam Friar and Matthew Ware)

3/6/2019

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Congratulations to Matt on admission to medical school and Liam for admission to graduate school!!!
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Congratulations to Kate Zulauf for Peggy Carter Travel Award to attend the ASM Microbe Meeting in San Francisco, CA!

2/27/2019

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The ASM Peggy Cotter Travel Award Program provides funds for early career branch members, in this case, the ASM Northeast Branch, to attend the ASM Microbe Meeting, to be held this year in San Francisco, CA.  Kate will be presented her work on a small molecule screen to evict CRE resistance plasmids.
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In vitro pharmacokinetics with a hollow fiber two compartment model

1/19/2019

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Gentian violet is diluted in hollow fiber cassette with a half life of approximately 4 hours based on dilution of initial "dose" in central compartment with fresh media at flow rate selected on peristaltic pump.  Next two antibiotics with different half lives.  Will the bacteria outside the hollow fibers survive and for how long? 
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Our first submission to Addgene

11/18/2018

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We have been taking advantage of Addgene for years. About to deposit about twenty plasmids form Yoon-Suk Kang's bioreporter tool kit.  Assembling plasmid maps in SnapGene.  Thank you, Addgene!
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GraphPad Prism

9/23/2018

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Excel and Powerpoint have been banned for figure preparation.  Converted my lab over to GraphPad Prism. A very well designed graphing and statistics program. Love several features including the ability to apply standard dimension formats for charts, and wand tool to covert charts to exact format used previously. Application of statistics to data is facile, also a wand tool to apply the same statistics to multiple tables. Grateful to Assay and Drug Development Technology for their requirement (recommendation?) to use this or similar programs in figure preparation.  Powerpoint never worked well for figure preparation and conversion to vector-graphics format, for use with illustrator was a nightmare. Now we just start out using a freeware vector graphics program or Adobe Illustrator directly.  Greatly speeds up manuscript preparation.  
P.S.  I  have no financial relationship with GraphPad Prism, but it is a good product so therefore my endorsement!
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Latex beads enter lysosomal pathway in J774A.1 macrophages - LAMP-1 staining

3/19/2018

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Staining with LAMP-1, a lysosomal marker
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Green fluorescent latex beads
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Merged image. Note latex beads are surrounded by LAMP-1 and are therefore in lysosomal compartments. Far-Red staining of LAMP-1 reduces amount of background autofluorescence
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Fun with Inkjet Printer

3/15/2018

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Lab art with HP D300 digital dispensing system. Crystal violet blue, phenol red, background droplets.
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  • Home
  • Antimicrobials
    • Legionella pneumophila
    • T4SS-dependent Gram negative pathogens
    • CRE Pathogens
    • Mechanisms of carbapenem resistance >
      • Carbapenemases | KPC | NDM-1
      • Porins
      • Efflux pumps
  • Diagnostics
  • SARS-CoV-2
  • Pathogenesis
  • About the PI
  • Personnel
  • Publications
  • Blog
  • Environment
  • Positions
  • Resources
  • Major Equipment
  • Donations
  • Comments
  • Contact Info
  • Internal Lab Resources