New combinations and repurposed antibiotics active against the pandrug-resistant Nevada CRE, NDM-1 strain early release today in AAC
Our latest manuscript: "Synergistic combinations and repurposed antibiotics active against the pandrug-resistant Klebsiella pneumoniae Nevada strain." Antimicrobial Agents and Chemotherapy early release identifies:
Highly synergistic activity of several antimicrobial combinations.
Low apramycin and spectinomycin MIC values.
CDC previously reported that none of 26 antimicrobials they tested were active against the Nevada strain. That made the strain until now pandrug-resistant.
Links to several news articles about this pandrug-resistant strain::
The Atlantic. NPR, NBC, PBS. Forbes
"3 Drug Combinations Appear Effective Against C auris" by Jared Kaltwasser discussed work presented by Thea Brennan-Krohn at ASM Microbe 2019.
There is a very fancy drawing of a single cell life form on the slide undoubtedly being compromised by a combination of antimicrobial therapeutics applied in Thea, Liam, and Sarah's experiments!
Postdoctoral Fellow Yoon-Suk Kang's Brucella chemical genetics screen early release today in Infection and Immunity
Congratulations to Yoon-Suk on his latest Brucella neotomae manuscript: "A chemical genetics screen reveals influence of p38 map kinase and autophagy on phagosome development and intracellular replication of Brucella neotomae in macrophages"
A primer on use of inkjet printing and time-kill studies for combination antimicrobial susceptibility testing
Adopted by the CDC .in their Antimicrobial Resistance Laboratory Network based on our prior publications in Journal of Clinical Microbiology, Journal of Antimicrobial Chemotherapy, and Antimicrobial Agents and Chemotherapy for testing of aztreonam/ceftazidime-avibactam combination activity using inkjet printing. We provide a step by step video demonstration of assay setup in the Journal of Visualized Experimentation. Link to article landing page (PDF protocol access and video), "Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method" by Thea Brennan-Krohn and James E. Kirby.
Congratulions to postdoctoral fellow, KP Smith, for being selected for the Paul E Strandjord Young Investigator Award
KP's abstract was selected for the Paul E Strandjord Young Investigator Award from the Academy of Clinical Laboratory Physicians and Scientists (ACLPS). He will be given an oral presentation at the ACLPS annual meeting this coming June. ACLPS is the organization that represents and promotes the discipline of academic clinical pathologists. Congratulations KP!
ASM has reorganized their website. Their blogs are now impossible to find, They are now organized under author pages. Blogs from current and former research and/or clinical fellows:
KP Smith's blogs can be found at: www.asm.org/Biographies/Kenneth-(K-P-)-Smith
Rose Lee's blogs can be found at: www.asm.org/Biographies/Rose-Lee
Thea Brennan-Krohn's blogs can be found at: www.asm.org/Biographies/Thea-Brennan-Krohn
Jennifer Tsang's blogs can be found at: www.asm.org/Biographies/Jennifer-Tsang
Great week for graduate school/medical school admissions (congratulations to Liam Friar and Matthew Ware)
Congratulations to Matt on admission to medical school and Liam for admission to graduate school!!!
Congratulations to Kate Zulauf for Peggy Carter Travel Award to attend the ASM Microbe Meeting in San Francisco, CA!
The ASM Peggy Cotter Travel Award Program provides funds for early career branch members, in this case, the ASM Northeast Branch, to attend the ASM Microbe Meeting, to be held this year in San Francisco, CA. Kate will be presented her work on a small molecule screen to evict CRE resistance plasmids.
We are delighted to welcome our newest laboratory member. Matthew comes with an extensive engineering and systems background and will bring new expertise to the lab!
Kirby Lab Blog