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We are seeking college and high school students to help with experiments to develop new ways of treating infections using highly informative in vitro infection models in the laboratory. No prior laboratory experience necessary. Please see contact information under "Positions" to apply or learn move.
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Our New Year's Eve manuscript acceptance, full text posting on ACS Infectious Diseases. Congratulations to members of the Manetsch and Kirby Laboratories on on line publication of: "Development of CGS-15943 Adjunctives for the Disruption of Plasmid Maintenance in Multidrug Resistant E. coli."
The manuscript describes structure activity relationship studies on a small molecule scaffold CGS-15943. The parent compound causes complete eviction of an IncFIA plasmid with highly selectivity in low, single-digit micromolar concentrations. Kate Zulauf at al. previously described identification and characterization of several potent plasmid eviction compounds in our PNAS publication. In our ACS Infectious Diseases manuscript, one portion of MInte's PhD thesis, CGS-15943 analogs were identified which were more potent than the parent compound, and with increased penetrance, An exciting step forward in our plasmid eviction work. Undergraduate, Heidi Alhannat, takes over tissue culture incubator for natural product production7/13/2024  Forget CO2, Forget Temperature.
Selman Waksman step over! A big thumbs up! Ariane was immersed in antimicrobial resistance research on gram negatives in Ecuador prior to starting an internal medicine residency in 2022 at Salem Hospital and MGB. In her spare time during her medical training, she will be continuing her investigation of gram-negative resistance mechanism in the Kirby lab.
BAARN would not be complete without antimicrobial medicinal chemistry. Roman Manetsch and lab were there in force to highlight collaborative efforts on the streptothricin scaffold.  Left to Right: Roman Manetsch, Brandon Miller, Yuliya Marusyk  Kirby and Brennan-Krohn Labs at BAARN 2023 Meeting, Poster Session Memorial Hall, Harvard College. Left to Right: Yanqin Huang, Michelle Nägeli, Anusha Shukla, James Kirby, Alhanouf Aljahdali, Thea Brennan-Krohn, Matt Hernandez
Some Press Releases:
Researchers Show an Antibiotic Discovered 80 Years Ago Is Effective Against Multi-Drug Resistant Bacteria Neglected 80-year-old antibiotic is effective against multi-drug resistant bacteria Vergeten antibioticum kan uitkomst zijn in strijd tegen multiresistente bacteriën 
Streptothricin-F (yellow spheres) bound to 16S rRNA (green) of the bacterial ribosome impinges on the decoding site where the anti-codon stem loop of the A-site tRNA (purple) binds to the codon of the mRNA (blue). This bumping of streptothricin-F into the decoding site is associated with translational infidelity (insertion of amino acids into the growing peptide chain other than those encoded for by the mRNA), ultimately leading to poisoning and death of the bacterial cell. The image was created using Pymol by alignment of PDB 7UVX containing streptothricin-F (this manuscript) with the E. coli 70S ribosome from PDB 7K00 containing mRNA and the A-site tRNA shown (DOI: 10.7554/eLife.60482).
General areas include antimicrobial resistance, antimicrobial discovery, novel methods of treating antimicrobial resistant pathogens.
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