"The Inoculum Effect in the Era of Multidrug Resistance: Minor Differences in Inoculum Have Dramatic Effect on Minimal Inhibitory Concentration Determination."
The manuscript describes use of D300-based inkjet printing technology to investigate the inoculum effect with a resolution not previously possible. The inoculum effect is the general observation that the minimal inhibitor concentration (in other words level of resistance) of an organism to an antibiotic increases when a higher density of organisms is tested. This is effect is especially prominent for beta-lactam antiibiotics. It is of potential clinical concern during some types of infections when the organism burden is high. Here we explored whether subtle differences in inoculum within the range allowed by current standards can effect the susceptibility testing results that clinical laboratories obtain and provide to clinicians. Our findings for organisms with certain types of multidrug-resistance and very important classes of antibiotics was that these small allowable differences in inoculum could change the MIC determinations and the determination of whether organisms were susceptible or resistant to the antibiotics tested.
Interview by science and technology writer, Marc Landas. "CONVERSATIONS WITH JAMES KIRBY: TRAINING AI FOR INFECTIOUS DISEASE DIAGNOSTICS"
We are delighted to welcome our newest laboratory member. Matthew comes with an extensive engineering and systems background and will bring new expertise to the lab!
KP Smith wins an "Outstanding Abstract Award" otherwise known as the OAA, for his experimental work on the inoculum effect.
The award description on the ASM Microbe 2018 awards website: "Sponsored by ASM and determined by the ASM Microbe Program Committee, these awards highlight outstanding abstracts presented by students, residents, or medical/clinical fellows. All abstracts submitted by the deadline will be considered for these awards. Awards will include a cash prize of $200."
Divya is freshman at Northeastern University and will be joining the laboratory to study novel antimicrobial treatment strategies. Her first project will involve collaboration with our Beth Israel Deaconess Medical Center and Harvard Medical School pathology colleague, Anders Berg.
Our Gram stain artificial intelligence platform was selected as a competitor in the 2018 Stat Madness Competition.
Work from our laboratory was selected as a competitor in the 2018 StatMadness Competition. This bracket style national competition will allow voters to choose among important medical innovations developed at selected medical centers and universities across the United States. The artificial intelligence-based-platform named Technologist Assist allows automatic imaging and interpretation of Gram stain results and ultimately will provide assisted laboratory diagnostic capabilities at near or remote sites.
Please vote for our work at the Stat Madness website: www.statnews.com/feature/stat-madness/bracket/
We officially moved the lab today. Not very far. Just to other side of the floor. Doubled our bench space! We are all very excited!
Updates on lab activities