Postdoctoral Fellowship Position Available Immediately in the Laboratory of Ed Yu for Collaborative Studies to Investigate Interaction of Small Molecules with the Ribosome and RNA

A postdoctoral position is available immediately (4/2/2023) in the Laboratory of Ed Yu to study biology of the ribosome; mechanism of action of translational inhibitors; and interaction of small molecules with RNA in the Department of Pharmacology at Case Western Reserve. Projects are being performed collaboratively with the Kirby, Manetsch, and O'Doherty Laboratories. See recent manuscripts (PMC8805024, PMC8263017, PMC6974574)

The incoming research fellow will use x-ray crystallography/cryo-EM and other biophysical/biochemical techniques to elucidate the molecular mechanisms in these systems. Please find additional information about the Yu group and the outstanding training environment in the Case Western Department of Pharmacology website (https://case.edu/medicine/pharmacology/).

This position requires expertise in structural biology. The ideal candidate will have shown the ability to guide a project to completion, from protein expression to structural analysis. Knowledge of common structural programs (Phenix, Coot, Pymol) a must. Experience with cryo-electron microscopy sample preparation/operation/data analysis is highly desirable. Experience with single-molecule FRET and other biochemical and biophysical characterization methods would also be considered a strength.

Qualified applicants must have a PhD or MD/PhD degree; strong written, oral communication, and critical thinking skills are required. As a Postdoctoral Scholar, he/she will present data at departmental seminars, prepare manuscripts, and contribute preliminary data for grant proposals. Preference will be given to applicants with a recognized record of accomplishment as evidenced by scholarly publications in the field of bacteriology or structural biology. Send inquiries containing a cover letter, CV with list of publications and contact information to Dr. Edward Yu ([email protected]).

See also Ed' posting