We officially moved the lab today. Not very far. Just to other side of the floor. Doubled our bench space! We are all very excited!
Congratulations to Thea Brennan-Krohn on being awarded a five year K08 Mentored Clinical Scientist Research Career Development Award by the National Institutes of Health!
Research Associate Position | MAST | Beth Israel Deaconess Medical Center | Boston | Kirby Laboratory | Harvard Medical School
Seeking to hire a research associate to work on the MAST project (microscopy-based antimicrobial susceptibility testing. Please contact email@example.com and send a c.v., short statement of interest, and contact information for three references. The official BIDMC official posting is in the described as a research assistant in the pathology department.
Congratulations to lab members, Anthony Kang, and colleagues for our manuscript newly accepted in Antimicrobial Agents and Chemotherapy titled: "Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model"
The manuscripts describes potent in vitro and in vivo activity of the apramycin, an aminocyclitol aminoglycoside, against multidrug-resistant and extensively-drug resistant Acinetobacter baumannii.
In prior manuscripts, we demonstrated broad activity against several types of multidrug-resistant pathogens including carbapenem-resistant Enterobacteriaceae (CRE), Acinetobacter baumannii and Pseudomonas aeruginosa
The laboratory has been fortunate to participate in Harvard Catalyst Reactor Program through the "Big Ideas, Small Features” Pilot Grant Award. A description of the program was recently published last week in Harvard Medical School news titled "Catalyzing Research Innovation."
A description of the supported work can be found at: "Reactor Program Awards Eight New Pilot Grants: Supports researchers with novel solutions to major clinical challenges."
Thea was awarded an Academy of Clinical Laboratory Physicians and Scientists (ACLPS) Paul E. Strandjord Young Investigator Research Grant to study antimicrobial synergy against multidrug-resistant pathogens!
"These grants are for research relevant to clinical laboratory science, clinical pathology, and laboratory medicine. Proposed research may be clinical, translational, basic science, quality improvement, and/or regulatory.
As this grant program is designed for young investigators, grant recipients must either be in training (residency and/or clinical or research fellowship) OR less than three years after their first faculty appointment (any level) at the time of application" . (quoted from: http://www.aclps.org/grant.html)
In the past, there have been only three such awards given nationally in a given year.
Image from lab meeting! Spinning disk confocal microscope image of B. neotomae and J744A.1 macrophages
Spinning disc confocal microscopy image acquired by Lucius Chiaraviglio and presented at Lab Meeting this past Friday. A single multiply infected macrophage is shown. Red objects are individual Brucella neotomae bacteria. Green immunofluorescent staining lables LAMP-1, a marker of late endosomes and lysosomes. Brucella traffics to LAMP-1 compartments early during infection.
New article published online today in Journal of Clinical Microbiology - Artificial intelligence, A New Tool for Interpretation of Bacterial Gram Stains
."Automated Interpretation of Blood Culture Gram Stains using a Deep Convolutional Neural Network" was published online today in the Journal of Clinical Microbiology. Congratulations to co-first authors: postdoctoral fellow, KP Smith, and medical microbiology fellow, Anthony Kang.
The article describes use of artificial intelligence in combination with a Metafer (MetaSystems) automated microscope to automatically interpret blood culture Gram stains without human intervention.
Link to Abstract.
Link to final accepted manuscript file.
Updates on lab activities